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Symbol
Name
ID 		Ptgis
prostaglandin I2 (prostacyclin) synthase
MGI:1097156
Phenotype annotations related to cardiovascular system
Darker colors indicate more annotations
Human Phenotypes
Right ventricular dilatation
Right ventricular hypertrophy
Pulmonary arterial medial hypertrophy
Pulmonary aterial intimal fibrosis
Arterial intimal fibrosis
Stroke
Abnormal cardiovascular system physiology
Elevated right atrial pressure
Right ventricular failure
Abnormally loud pulmonic component of the second heart sound
Heart murmur
Tricuspid regurgitation
Elevated diastolic blood pressure
Elevated mean arterial pressure
Elevated systolic blood pressure
Hypertension
Elevated pulmonary artery pressure
Pulmonary arterial hypertension
Pulmonary arterial hypertension with lack of acute response to NO challenge
Increased pulmonary vascular resistance
Elevated jugular venous pressure
Palpitations
Atrial flutter
First degree atrioventricular block
Right bundle branch block
Angina pectoris
Syncope
Pulmonary artery vasoconstriction
Telangiectasia
Disease(s) Associated with PTGIS
cerebral infarction
essential hypertension
primary pulmonary hypertension

Mouse Phenotypes
abnormal aorta wall morphology
abnormal aorta tunica adventitia morphology
abnormal aorta tunica media morphology
abnormal thoracic aorta morphology
kidney vascular congestion
abnormal heart morphology
increased heart weight
enlarged heart
increased systemic arterial blood pressure
Availability Mouse Genotype
Ptgisem1(IMPC)Mbp/Ptgisem1(IMPC)Mbp
Ptgistm1Tada/Ptgistm1Tada
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory